Dctpp1 dCTP pyrophosphatase 1 [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Dctpp1provided by RGD
Official Full Name: dCTP pyrophosphatase 1provided by RGD
Primary source: RGD:620933
See related: Ensembl:ENSRNOG00000017850 AllianceGenome:RGD:620933
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as: Rs21c6; RS21-C6; Xtp3tpa
Summary: Predicted to enable several functions, including dCTP diphosphatase activity; magnesium ion binding activity; and pyrimidine deoxyribonucleotide binding activity. Predicted to be involved in DNA protection and dCTP catabolic process. Predicted to be located in mitochondrion and nucleus. Predicted to be active in cytosol. Orthologous to human DCTPP1 (dCTP pyrophosphatase 1). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Biased expression in Thymus (RPKM 132.0), Testes (RPKM 122.4) and 9 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: 1q37

Exon count:: 3

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	1	NC_086019.1 (191307933..191311326, complement)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	1	NC_051336.1 (181877440..181880833, complement)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	1	NC_005100.4 (198703459..198706852, complement)

Chromosome 1 - NC_086019.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

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General gene information

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Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables dCTP diphosphatase activity	IBA Inferred from Biological aspect of Ancestor more info
enables dCTP diphosphatase activity	ISO Inferred from Sequence Orthology more info
enables dCTP diphosphatase activity	ISS Inferred from Sequence or Structural Similarity more info
enables identical protein binding	ISO Inferred from Sequence Orthology more info
enables magnesium ion binding	ISO Inferred from Sequence Orthology more info
enables magnesium ion binding	ISS Inferred from Sequence or Structural Similarity more info
enables nucleoside triphosphate diphosphatase activity	ISO Inferred from Sequence Orthology more info
enables nucleoside triphosphate diphosphatase activity	ISS Inferred from Sequence or Structural Similarity more info
enables pyrimidine deoxyribonucleotide binding	ISO Inferred from Sequence Orthology more info
enables pyrophosphatase activity	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
involved_in DNA protection	IBA Inferred from Biological aspect of Ancestor more info
involved_in DNA protection	ISO Inferred from Sequence Orthology more info
involved_in DNA protection	ISS Inferred from Sequence or Structural Similarity more info
involved_in dCTP catabolic process	IBA Inferred from Biological aspect of Ancestor more info
involved_in dCTP catabolic process	ISO Inferred from Sequence Orthology more info
involved_in dCTP catabolic process	ISS Inferred from Sequence or Structural Similarity more info
NOT involved_in dTTP catabolic process	ISO Inferred from Sequence Orthology more info
involved_in nucleoside triphosphate catabolic process	ISO Inferred from Sequence Orthology more info
involved_in nucleoside triphosphate catabolic process	ISS Inferred from Sequence or Structural Similarity more info

Component	Evidence Code	Pubs
is_active_in cytosol	IBA Inferred from Biological aspect of Ancestor more info
located_in cytosol	ISO Inferred from Sequence Orthology more info
located_in cytosol	ISS Inferred from Sequence or Structural Similarity more info
NOT located_in mitochondrion	ISO Inferred from Sequence Orthology more info
located_in mitochondrion	ISO Inferred from Sequence Orthology more info
located_in mitochondrion	ISS Inferred from Sequence or Structural Similarity more info
located_in nucleoplasm	ISO Inferred from Sequence Orthology more info
NOT located_in nucleus	ISO Inferred from Sequence Orthology more info
located_in nucleus	ISO Inferred from Sequence Orthology more info
located_in nucleus	ISS Inferred from Sequence or Structural Similarity more info

General protein information

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Preferred Names: dCTP pyrophosphatase 1

Names: XTP3-transactivated gene A protein homolog; XTP3-transactivated protein A; dCTPase 1; deoxycytidine-triphosphatase 1

NP_620247.1

EC 3.6.1.12

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_138892.1 → NP_620247.1 dCTP pyrophosphatase 1

See identical proteins and their annotated locations for NP_620247.1

Status: PROVISIONAL

Source sequence(s)

AY029335

UniProtKB/Swiss-Prot

Q91VC0

UniProtKB/TrEMBL

A6I9N7

Related

ENSRNOP00000024074.2, ENSRNOT00000024074.5

Conserved Domains (1) summary

cd11537
Location:35 → 125

NTP-PPase_RS21-C6_like; Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) MazG-like domain found in mouse RS21-C6 protein and its homologs